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integrin α5β1 inhibitor  (MedChemExpress)


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    MedChemExpress integrin α5β1 inhibitor
    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and <t>α5β1</t> positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).
    Integrin α5β1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 15 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/integrin α5β1 inhibitor/product/MedChemExpress
    Average 93 stars, based on 15 article reviews
    integrin α5β1 inhibitor - by Bioz Stars, 2026-05
    93/100 stars

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    1) Product Images from "Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair"

    Article Title: Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair

    Journal: Bioactive Materials

    doi: 10.1016/j.bioactmat.2026.03.017

    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).
    Figure Legend Snippet: Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).

    Techniques Used: Activation Assay, Membrane, Fluorescence, Microscopy, Comparison, Flow Cytometry



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    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and <t>α5β1</t> positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).
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    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and <t>α5β1</t> positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).
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    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin <t>αvβ1</t> and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).
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    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).

    Journal: Bioactive Materials

    Article Title: Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair

    doi: 10.1016/j.bioactmat.2026.03.017

    Figure Lengend Snippet: Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).

    Article Snippet: TRPC1 inhibitor (0.3 nM, Pico145, CAS No. 1628287-16-0), TRPM7 inhibitor (1.0 μM, VPC4, CAS No. 945604-76-2), TRPV2 inhibitor (5.0 μM, compound IV2-1, CAS No. 2242724-49-6), TRPM4 inhibitor (1.5 μM, CBA, CAS No. 351424-20-9), PIEZO1 inhibitor (2.5 μM, GsMTx4, CAS No. 1209500-46-8), integrin αvβ5 inhibitor (8.0 nM, Compound 12, CAS No.: 2615912-33-7), integrin αvβ1 inhibitor (0.3 nM, Compound C8, CAS No. 1689540-62-2), integrin α5β1 inhibitor (10 μM, ATN-161, 904763-27-5), and CDK5 inhibitor (5 nM, CDK5-IN-1, 2,639,540-19-3) were purchased from MCE Biotechnology Co., LTD. After the MSCs were treated, the cRGD solution was added at a concentration of 1:200 and incubated in the dark for 15 min, and the results were observed by fluorescence microscopy.

    Techniques: Activation Assay, Membrane, Fluorescence, Microscopy, Comparison, Flow Cytometry

    Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).

    Journal: Bioactive Materials

    Article Title: Mechanically sensitized hydrogel microspheres trigger membrane receptor switch for cartilage repair

    doi: 10.1016/j.bioactmat.2026.03.017

    Figure Lengend Snippet: Integrin receptor activation induced by membrane receptor switch. A) The fluorescence microscopy of MSCs loaded on HAMA or OBNC hydrogel after different treatments. B) Relative fluorescence intensity in the whole field of view for each group. C) Relative fluorescence intensity per cell for each group (∗ symbol represents comparison with HAMA group, # symbol represents comparison with OBNC group). D) Flow cytometry was used to detect integrin αvβ1 and α5β1 positive cells. E) Relative fluorescence intensity of each group. F) Flow cytometry was used to detect 12G10 positive cells and within integrin αvβ1 and α5β1 positive cells. G) Relative fluorescence intensity of each group, and relative proportions of 12G10 to integrins αvβ1 and α5β1. (ns: non-significant, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001, ## P < 0.01, ### P < 0.001).

    Article Snippet: TRPC1 inhibitor (0.3 nM, Pico145, CAS No. 1628287-16-0), TRPM7 inhibitor (1.0 μM, VPC4, CAS No. 945604-76-2), TRPV2 inhibitor (5.0 μM, compound IV2-1, CAS No. 2242724-49-6), TRPM4 inhibitor (1.5 μM, CBA, CAS No. 351424-20-9), PIEZO1 inhibitor (2.5 μM, GsMTx4, CAS No. 1209500-46-8), integrin αvβ5 inhibitor (8.0 nM, Compound 12, CAS No.: 2615912-33-7), integrin αvβ1 inhibitor (0.3 nM, Compound C8, CAS No. 1689540-62-2), integrin α5β1 inhibitor (10 μM, ATN-161, 904763-27-5), and CDK5 inhibitor (5 nM, CDK5-IN-1, 2,639,540-19-3) were purchased from MCE Biotechnology Co., LTD. After the MSCs were treated, the cRGD solution was added at a concentration of 1:200 and incubated in the dark for 15 min, and the results were observed by fluorescence microscopy.

    Techniques: Activation Assay, Membrane, Fluorescence, Microscopy, Comparison, Flow Cytometry